发明名称 |
IMPROVED NOGO-A BINDING MOLECULES AND PHARMACEUTICAL USE THEREOF |
摘要 |
<p>The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system; a pharmaceutical composition comprising said binding molecule; and a method of treatment of a disease of the peripheral (PNS) and/or central (CNS) nervous system.</p> |
申请公布号 |
KR20100100848(A) |
申请公布日期 |
2010.09.15 |
申请号 |
KR20107012080 |
申请日期 |
2008.10.27 |
申请人 |
NOVARTIS AG;UNIVERSITY OF ZURICH |
发明人 |
BARSKE CARMEN;FRENTZEL STEFAN;MIR ANIS KHURSO;SCHWAB MARTIN E.;VITALITI ALESSANDRA |
分类号 |
C07K16/22;A61K39/395;A61P25/00;C12N15/63 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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