| 摘要 |
#CMT# #/CMT# Agent comprises a disulfide compound (I) or its acid addition salts. #CMT# : #/CMT# Agent comprises a disulfide compound of formula (I) or its acid addition salts. X : NH or bond; and n : 2-4, preferably 2 or 3. An independent claim is included for a dermatologically active composition comprising (I), at least a skin care active agent comprising active ingredients for skin bleaching, depigmentation, sun protection and blocking UV rays, and optionally a carrier. #CMT#[Image]#/CMT# #CMT#USE : #/CMT# The agent is useful: as skin bleaching agent for bleaching age spots and pigment spots; to compensate irregularities in skin coloration; in cosmetic or dermatological preparation, such as sun protection products, deodorants, and soaps and liquid synthetic detergents; and in a formulation having a pH value of 3-11, preferably 3-6.5 (all claimed). #CMT#ADVANTAGE : #/CMT# The agent exhibits high efficiency at low concentration, no toxicity, high compatibility, and improved skin tolerability, and is easy to apply on the skin. #CMT#ORGANIC CHEMISTRY : #/CMT# Preferred Components: The agent contains 0.005-20 (preferably 0.05-5) wt./wt.% of (I). (I) is 2-[2-(3,4,5,6-tetrahydropyrimidinyl)amino]ethyl-disulfide. #CMT#ADMINISTRATION : #/CMT# Administration of the agent is topical (claimed). No dosage details given. #CMT#EXAMPLE : #/CMT# Typical sun protection cream comprised (in wt.%) of: Amphisol K(RTM: Potassium cetyl phosphate) (2); Tegosoft CT(RTM: Caprylic/capric triglyceride) (4); Tegosoft TN(RTM: 12-15C Alkyl benzoate) (4); Cetiol SN(RTM: Cetearyl isononanoate) (1); Tegin(RTM: Glyceryl stearate) (3); cetyl alcohol (1); Uvinul T150(RTM: Ethylhexyl triazone) (0.50); Tinosorb OMC(RTM: Ethylhexyl methoxycinnamate) (3); water (64.75); glycerin (3); Keltrol RD(RTM: Xanthan gum) (0.25); Tinosorb M(RTM: Methylene-bis-benzotriazolyl tetramethylbutylphenol) (8); ethoxydiglycol (5); citric acid (sufficient quantity); N,N'-(2,2'-disulfanediylbis(ethane-2,1-diyl))bis(1,4,5,6-tetrahydropyrimidin-2-amine) (0.50); and preservatives (sufficient quantity). |
