| 摘要 |
THIS INVENTION CONCERNS SUBSTITUTED DIAZA-SPIRO-[5.5]-UNDECANE DERIVATIVES HAVING NEUROKININ ANTAGONISTIC ACTIVITY, IN PARTICULAR NK₁ ANTAGONISTIC ACTIVITY,A COMBINED NK₁/NK₂ ANTAGONISTIC ACTIVITY, A COMBINED NK₁/NK₃ ANTAGONISTIC ACTIVITY AND A COMBINED NK₁/NK₂/NK₃ ANTAGONISTIC ACTIVITY, THIER PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE, IN PARTICULAR FOR THE TREATMENT AND/OR PROPHYLAXIS OF SCHIZOPHRENIA, EMESIS, ANXIETY AND DEPRESSION, IRRITABLE BOWEL SYNDROME (IBS), CIRACADIAN RHYTHM DISTURBANCES, PRE-ECLAMPSIA, NOCICEPTION, PAIN, IN PARTICULAR VISCERAL AND NEURAOPHATIC PAIN, PANCREATITIS, NEUROGENIC INFLAMMATION, ASTHMA, COPD AND MICTURITION DISORDERS SUCH AS URINARY INCONTINENCE. THE COMPOUNDS ACCORDING TO THE INVENTION CAN BE REPRESENTED BY GENERAL FORMULA (1) AND COMPRISES ALSO THE PHARMACEUTICALLY ACCEPTABLE ACID OR BASE ADDITION SALTS THEREOF, THE STREOCHEMICALLY ISOMERIC FORMS THEREOF, THE N-OXIDE FORM THEREOF AND PRODRUGS THEREOF, WHEREIN ALL SUBSTITUENTS ARE DEFINED AS IN CLAIM 1.
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