发明名称 |
Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins |
摘要 |
Anti-cancer agents and/or transforming growth factor beta (TGF-beta or TGF&bgr;) antagonists are disclosed, where the agents and/or antagonists include a therapeutically effective amount of a combination of therapeutically active portions of sRII and therapeutically active portions of sRIII or a fusion polypeptide or protein comprising therapeutically active portions of sRII and therapeutically active portions of sRIII. Methods for preventing, treating and/or ameliorating the symptoms of cancer are also disclosed based on administering an effective amount of a composition of this invention.
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申请公布号 |
US7795389(B2) |
申请公布日期 |
2010.09.14 |
申请号 |
US20050238172 |
申请日期 |
2005.09.28 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SUN LUZHE;HINCK ANDREW P. |
分类号 |
C07K14/00;A61K38/00;A61K38/16 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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