发明名称 |
PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF |
摘要 |
The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of .alpha.-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invention, the process of alkylating an aldimine-type Schiff base in a medium in the presence of an optically-active quaternary ammonium salt phase-transfer catalyst and an inorganic base is initiated, and subsequently the reaction is quenched at a time earlier than a time for completion of the stoichiometric reaction of the alkylation reaction, so that a mono-substituted alkylated product with high optical purity can be obtained.
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申请公布号 |
CA2610776(C) |
申请公布日期 |
2010.09.14 |
申请号 |
CA20062610776 |
申请日期 |
2006.07.28 |
申请人 |
NAGASE & CO., LTD. |
发明人 |
MARUOKA, KEIJI;INOUE, TORU;MATSUMOTO, JUN |
分类号 |
C07C249/02;B01J31/02;C07B53/00;C07B61/00;C07C227/04;C07C229/36;C07C251/24 |
主分类号 |
C07C249/02 |
代理机构 |
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地址 |
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