发明名称 Substituted pyrimidinones
摘要 Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
申请公布号 US7795271(B2) 申请公布日期 2010.09.14
申请号 US20090434906 申请日期 2009.05.04
申请人 PHARMACIA CORPORATION 发明人 DURLEY RICHARD C.
分类号 A61K31/513;A61K31/506;A61K31/5375;A61K31/541;A61P29/00;C07D239/46;C07D239/52;C07D401/06;C07D403/06;C07D403/10;C07D403/12;C07D405/04;C07D405/12;C07D413/06;C07D417/06 主分类号 A61K31/513
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