发明名称 |
Gab1 involvement in glucose homeostasis regulation by hepatocytes |
摘要 |
The invention is directed to the regulation of glucose homeostasis by modulating the activity of Grb2-associated binder 1 (Gab1) in hepatocytes. This invention also provides for a method for identifying compounds capable of modulating the glucose homeostasis regulatory activity of Gab1. In one aspect, the invention provides a method for identifying a compound that can effectively modulate glucose homeostasis wherein Gabl mediated MapK activity indicates that the candidate compound is an effective compound that modulates glucose homeostasis. In another aspect, the invention provides a method for identifying a compound that can effectively modulate the glucose homeostasis regulating activity of Gabl wherein MAPK is activated to phosphorylate Serine residue 612 of IRS-1, indicating that the candidate compound is an effective compound that modulates glucose homeostasis. In another aspect of the invention is provided a method for diagnosing Gab1 related disorders.
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申请公布号 |
US7794956(B2) |
申请公布日期 |
2010.09.14 |
申请号 |
US20040987384 |
申请日期 |
2004.11.12 |
申请人 |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
FENG GEN-SHENG;CHAPEAU EMILIE |
分类号 |
G01N33/567;A01K67/027;A61K38/00;C12N5/02;C12Q1/00;G01N33/66 |
主分类号 |
G01N33/567 |
代理机构 |
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主权项 |
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地址 |
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