NOVEL TUMOR ANTIGEN PROTEIN AGR2 AND TUMOR ANTIGENPEPTIDE THEREOF

摘要

PURPOSE: A novel tumor antigen protein AGR2 and tumor antigenic peptide thereof are provided to induce tumor-specific cytotoxicity immune response. CONSTITUTION: A cellular immunotherapeutic agent composition for preventing or treating colorectal cancer comprises dendritic cells having human AGR2(anterior gradient-2) tumor antigenic peptide with an amino sequences of sequence number 6 or 12 or AGR2-specific cytotoxic T lymphocytes which is secreted from the dendritic cells as active ingredients. A method for manufacturing cellular immunotherapeutic agent composition for treating or preventing colorectal cancer comprises: a step of loading the human AGR2 tumor antigenic peptide; and a step of co-culturing the loaded dendritic cells and T lymphocytes.