发明名称 |
Covalently immobilized fluorinated carboxylic acid stationary phase for liquid chromatography |
摘要 |
A stationary phase for a liquid chromatograph and process for making is provided. The stationary phase material may have a modified base substrate and a fluorinated carboxylic acid covalently bonded thereto through an amide or ester bond. The stationary phase may have a substantially consistent shape selectivity characteristic with anαTBN/BaP of less than 1 within a temperature range of at least 10-70° C. Advantageously, a fluorinated stationary phase has a shape selectivity characteristic exhibited with anαTBN/BaP of less than 1 with a mobile phase having up to at least 30% water. A process for making the stationary involves mixing a substrate material or fluorinated carboxylic acid with a reactive alkylsilane linker and at least one organic solvent to form a first solution. The other of the substrate material or fluorinated carboxylic acid is then added to the first solution, or to a product separated from the first solution, to form a second solution. The second solution is reacted to form the stationary phase.
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申请公布号 |
US7794837(B2) |
申请公布日期 |
2010.09.14 |
申请号 |
US20080186728 |
申请日期 |
2008.08.06 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF COMMERCE, THE NATIONAL INSTITUTE OFSTANDARDS AND TECHNOLOGY |
发明人 |
LIPPA KATRICE A.;RIMMER CATHERINE A.;SANDER LANE C. |
分类号 |
B32B9/04 |
主分类号 |
B32B9/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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