13.13-DIMETHYL-DES-C,D ANALOGS OF 1ALPHA, 25-DIHYDROXY-19-NOR-VIT AMIN D3 COMPOUNDS AND TOPICAL COMPOSITION DOSAGE FORMS AND METHODS OF TREATING SKIN CONDITIONS.

摘要

13,13-Dimethyl-flfes-C,D analogs of lα,25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms thereof, and methods of treating skin conditions thereof. Exemplary active pharmaceutical ingredients include (lR,3R)-5-[(E)-(S)-11'-hydroxy- 5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-l,3-di ol, (lR,3R)-5-[(Z)-(S)-11 '-hydroxy-5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene-cyclohexane-l,3-di ol, (lR,3R)-5-[(E)-(R)-l 1 '-hydroxy-5',5',7',11 '-tetramethyl-dodec-2'-enylidene]-2-metylene- cyclohexane-l,3-diol, and (lR,3R)-5-[(Z)-(R)-11'-hydroxy-5',5',7',11'-tetramethyl-dodec-2 '- enylidene] -2-metylene-cyclohexane- 1,3 -diol.