| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to pharmaceutical industry. A supercritical liquid extract of Nerium oleander or Thevetia nerifolia leaves where the extract is prepared by supercritical carbon dioxide liquid extraction; in addition, a supercritical medium contains a modifying agent. The supercritical liquid extract containing oleandrine and another pharmacologically active agent extracted by the supercritical liquid. A pharmaceutical drug containing the supercritical liquid extract for treating a malignant neoplastic disease, cancer, tumour, virus infection or a nonneoplastic inflammatory disease of a skin. A method of treating a disease or disorder answering to a therapeutic cardiac glycoside treatment. A method of inhibition or reduction of degree of Akt phosphorilation in a cancer cell. A method of increasing pERK expression in a cancer cell. A method of inhibition of cancer cell proliferation. A method of supercritical liquid extraction. ^ EFFECT: higher anticancer, antiviral activity. ^ 23 cl, 3 dwg, 18 tbl, 13 ex |
