The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibing the ubiquitination activity of the APC by administering compositions of the invention.
申请公布号
WO2010102281(A2)
申请公布日期
2010.09.10
申请号
WO2010US26505
申请日期
2010.03.08
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;KING, RANDALL;ZENG, XING;GAUR, SHANTANU
