COMPOSITIONS AND METHODS FOR THE INHIBITION OF CRIPTO/GRP78 COMPLEX FORMATION AND SIGNALING
摘要
The present invention provides methods compositions and methods for treating a hyperproliferative disease comprising disrupting Cripto/GRP78 complex formation in a hyperproliferative cell. In certain embodiments, an antibody and/or siRNA may be used to inhibit Cripto/GRP78 binding, optionally coupled with other cancer therapies. Also provided are methods for identifying therapeutic compounds which can selectively inhibit Cripto/GRP78 binding.
申请公布号
WO2010054328(A3)
申请公布日期
2010.09.10
申请号
WO2009US63748
申请日期
2009.11.09
申请人
RESEARCH DEVELOPMENT FOUNDATION;GRAY, PETER, C.;SHANI, GIDI;KELBER, JONATHAN, A.;VALE, WYLIE