发明名称 |
COMPOSITIONS AND METHODS FOR MODULATION OF CELL MIGRATION |
摘要 |
A peptide includes SEQ ID NO:3, substitution and addition variants thereof which maintain the ability to activate CD44. A complex includes this peptide or an A6 polypeptide with a CD44 polypeptide. An isolated polypeptide includes the Link region sequence of human CD44, functionally active fragments thereof, substitution variants, and addition variants. A method of treating a disease characterized by aberrant cell migration and/or invasion includes administering to a subject an effective amount of the peptide of SEQ ID NO:3 or an Å6 polypeptide to bind to a CD44 polypeptide and modulate signal transduction activity for a sufficient period of time to treat the disease. Other methods include using the peptide of SEQ ID NO:3 or an Å6 polypeptide for diagnosing, identifying a subpopulation of subjects responsive to treatment, and screening for compounds that bind a CD44 polypeptide. |
申请公布号 |
WO2010102253(A2) |
申请公布日期 |
2010.09.10 |
申请号 |
WO2010US26428 |
申请日期 |
2010.03.05 |
申请人 |
ANGSTROM PHARMACEUTICALS, INC.;FINLAYSON, MALCOLM;DAMAJ, BASSAM |
发明人 |
FINLAYSON, MALCOLM;DAMAJ, BASSAM |
分类号 |
A61K38/17 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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