METHOD OF PREPARING EZETIMIBE AND INTERMEDIATES USED THEREIN
摘要
Disclosed is a method for preparing ezetimibe which is effective for preventing or treating arteriosclerosis, and novel intermediates used therein. In accordance with the method which does not use expensive reagents, unwanted diastereoisomers can be easily removed by a step-by-step crystallization procedure, and the ezetimibe of formula 1 can be prepared in a high yield without the use of a hydrogenation procedure under a high pressure.
申请公布号
WO2010071358(A3)
申请公布日期
2010.09.10
申请号
WO2009KR07535
申请日期
2009.12.16
申请人
HANMI PHARM. CO., LTD.;KIM, GI JEONG;KIM, CHOONG HAHN;CHANG, JI YEON;KIM, NAM DU;CHANG, YOUNG KIL;LEE, GWAN SUN
发明人
KIM, GI JEONG;KIM, CHOONG HAHN;CHANG, JI YEON;KIM, NAM DU;CHANG, YOUNG KIL;LEE, GWAN SUN