| 发明名称 |
TEMPERATURE SENSITIVE MUTANTS OF MATRIX METALLOPROTEASE 1 UND USES THEREOF |
| 摘要 |
<p>Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.</p> |
| 申请公布号 |
CA2754461(A1) |
申请公布日期 |
2010.09.10 |
| 申请号 |
CA20102754461 |
申请日期 |
2010.03.05 |
| 申请人 |
HALOZYME, INC. |
发明人 |
BOOKBINDER, LOUIS;FROST, GREGORY I.;KELLER, GILBERT A.;FREY, GERHARD JOHANN;CHANG, HWAI WEN;SHORT, JAY MILTON |
| 分类号 |
A61K38/48;C07K14/435 |
主分类号 |
A61K38/48 |
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