BISTHIAZOLE COMPOUNDS THAT CAN BE USED TO TREAT CANCER

摘要

The invention relates to compounds having formula (I), the pharmaceutically acceptable salts thereof, or the solvates of same, wherein: Ri is selected from phenyl, optionally mono-, di- or tri-substituted with a radical independently selected from F, Cl, Br, I, (C1C4)-alkyl, N,N-(C1,C4)-alkylamino, hydroxy, (C1C4)-alkoxy, phenoxy, methylenedioxy, trifluoromethoxy, trifluoromethyl, carboxyl, 4-phenoxyphenyl and (C1C4)-alkoxycarbonyl; 2-thiazolyl; 2-pyridinyl; 2,2'-bipyridinyl; 2,2'-bisthiazole; naphthyl; 4-phenoxyphenyl and isoquinolyl; R2 is selected from the same group as R1 and, in addition, is independent of H and I; and R3 and R4 are selected independently from H, Br and F. Said compounds inhibit cell proliferation of tumour cells independently of the p53 protein and can likewise induce apoptosis in different tumour cells independently of the p53 protein, making same suitable for use in the treatment of different types of cancer. Formula (I)