| 摘要 |
PROBLEM TO BE SOLVED: To provide new tetracycline derivatives having modified dose-responsive profile or desired histological distribution profile. SOLUTION: There are provide, at least in part, the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells, are provided. Use of certain substituted tetracycline compounds, as featured in the methods, results in improved dose-response results when compared to those for e.g. tetracycline and doxycycline. COPYRIGHT: (C)2010,JPO&INPIT
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