| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide an aryl urea compound useful for treating raf mediated diseases, p38 mediated diseases and VEGF mediated diseases. <P>SOLUTION: There are provided a compound of formula (I) [wherein, Y is OR<SP>1</SP>or NHR<SP>2</SP>; Hal is Cl or Br; R<SP>1</SP>is H or 1-6C alkyl; R<SP>2</SP>is H, OH; Z<SP>1</SP>and Z<SP>2</SP>are each H or OH; only one of Z<SP>1</SP>and Z<SP>2</SP>may be OH; X<SP>1</SP>to X<SP>7</SP>are each independently OH or O(CO) 1-4C alkyl; (n) is 1, under the condition that at least one of the followings: (a) Z<SP>1</SP>or Z<SP>2</SP>is OH, and (b) R<SP>2</SP>is OH is satisfied], or a salt thereof, or an isolated stereoisomer thereof. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
