The present invention concerns the field of cell culture technology. It describes a novel method for enhancing the secretory transport of proteins in eukaryotic cells by heterologous expression of Munc18c, Sly1 or other members of the SM protein family. This method is particularly useful for the generation of optimized host cell systems with enhanced production capacity for the expression and manufacture of recombinant protein products.
申请公布号
EP2225389(A1)
申请公布日期
2010.09.08
申请号
EP20080864314
申请日期
2008.12.19
申请人
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
发明人
KAUFMANN, HITTO;BECKER, ERIC;FLORIN, LORE;FUSSENEGGER, MARTIN;PENG, REN-WANG;STUDTS, JOEY, M.