Process for determining the optimal dosage of antivitamins K in anticoagulant therapy

摘要

Determining optimal dosage (D o) of vitamin K, comprises: recording value I oof optimal target INR; recording international normalized ratio (INR) values measured in a time T 1; from a gradient P 1, extrapolating and recording a I maxvalue of INR theoretically reached from the day; recording INR values measured in a period T 2; from the gradient P2, extrapolating and recording a INR I minivalue theoretically reached from the day; calculating difference between INR I maxiand I minivalues and a factor F; and determining the difference between values I oand I mini. Determining optimal dosage (D o) of vitamin K for anticoagulant therapy for achieving and constantly maintaining the value of international normalized ratio (INR) target I opreviously determined by the prescriber according to the pathology of the treated patient, comprises: (a) recording the I ovalue of the optimal target INR; (b) recording the INR values measured in a given time (T 1) by an over dose (D maxi) of the antivitamin K previously determined by the prescriber over the recommended dosage, for determining a first gradient (P 1) of INR values according to the time T 1; (c) from the gradient P 1, extrapolating and recording a I maxvalue of INR theoretically reached from the day where the value I oof the target INR is reached and at the end of a determined period T o; recording the INR values measured in a given period T 2from an underdosing D miniof the antivitamin K fixed by the prescriber below the recommended dosage, for determining a second gradient P 2of values INR according to the time T 2; (d) from the gradient P2, extrapolating and recording a INR I minivalue theoretically reached from the day where the value I oof the target INR is reached and at the end of the fixed period T 0; (e) calculating the difference between the theoretically calculated INR I maxiand I minivalues, a factor F for correcting dose of the antivitamin K expressed by a formula as given in the specification; (g) determining the difference between the values I oof the optimal target INR and I miniof the calculated INR minimum, and the F factor for correcting the antivitamin K dose, the suitable dose D ofor achieving and maintaining a constant value I oof previously fixed INR target using a formula as given in the specification.