| 发明名称 |
Mutations in the BCR-Abl-tyrosine kinase associated with resistance to STI-571 |
| 摘要 |
The invention described herein relates to novel genes and their encoded proteins, termed M utants A ssociated with R esistance to STI-571 (e.g.,T3151 Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS. |
| 申请公布号 |
EP2186901(A3) |
申请公布日期 |
2010.09.08 |
| 申请号 |
EP20090006390 |
申请日期 |
2002.06.14 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SAWYERS, CHARLES L.;GORRE, MERCEDES E.;SHAH, NEIL PRAVIN;NICOLL, JOHN |
| 分类号 |
C12N15/09;C12N15/54;A61K31/505;A61K31/519;A61K38/17;A61P35/00;C07D239/42;C07D471/04;C07K14/82;C12N5/10;C12N9/12;C12Q1/48;C12Q1/68;G01N33/50;G01N33/574 |
主分类号 |
C12N15/09 |
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