发明名称 |
Methods for treating neurological deficits by intrastriatal administration of transforming growth factor alpha (TGF-α) |
摘要 |
The present invention features methods and compositions for treating a patient who has a neurological deficit. The method can be carried out, for example, by contacting (in vivo or in culture) a neural progenitor cell of the patient's central nervous system (CNS) with a polypeptide that binds the epidermal growth factor (EGF) receptor and directing progeny of the proliferating progenitor cells to migrate en masse to a region of the CNS in which they will reside and function in a manner sufficient to reduce the neurological deficit. The method may include a further step in which the progeny of the neural precursor cells are contacted with a compound that stimulates differentiation.
|
申请公布号 |
US7790669(B1) |
申请公布日期 |
2010.09.07 |
申请号 |
US19980129028 |
申请日期 |
1998.08.04 |
申请人 |
NEUROREPAIR, INC. |
发明人 |
REID JAMES STEVEN;FALLON JAMES H. |
分类号 |
A61K38/00;A61K45/06;A61K38/18;A61K38/22;A61K49/00;A61P25/28;A61P27/02;C07K14/00;C12N5/00;C12N5/07;C12N5/079;C12N5/0793;C12N5/0797 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|