PRODUCTION PROCESS FOR POLYMERIC MICELLE CHARGED THEREIN WITH DRUG AND POLYMERIC MICELLE COMPOSITION

摘要

Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition con-taining such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to pre-pare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.