| 摘要 |
PURPOSE: A peptide antigen with enhanced immunogenicity and a method for producing the same are provided to enhance immunogenicity and to increase antibody production efficiency. CONSTITUTION: A peptide antigen with enhanced immunogenicity comprises an amino acid sequence with two or more tandem repeat amino acid sequence unit. The peptide antigen additionally contains proline between amino acid sequence units. A vaccine composition contains the peptide antigen, nucleic acid encoding the same, or antibody to the peptide antigen. A method for producing the peptide antigen with immunogenicity comprises: a step of determining amino acid sequence corresponding to an epitope of a target antigen; and a step of preparing a polypeptide comprising two or more tandem repeat amino acid sequence units; or a step of preparing amino acid sequence which additionally contains proline.
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