ß-AMINOCARBONYL COMPOUND MANUFACTURING METHOD AND LITHIUM BINAPHTHOLATE COMPLEXES

摘要

Optically active ß-aminocarbonyl compounds are obtained by a Mannich reaction of an optically active binaphthol represented by formula (1a), (1b), (2a) or (2b) (in each formula, Ar1 is a phenyl group wherein hydrogen atoms are bound to the two ortho-positions and R1 is a hydrogen atom, halogen or alkyl group) with a protected nitrogen aldimine compound and a carbonyl compound in the presence of 1-2 times in moles, relative to said binaphthol, of alkyl lithium, lithium alkoxide or lithium hydroxide as a lithium source.