发明名称 |
PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE |
摘要 |
<p>The invention is to provide a novel anticancer agent or sensitizer for cancer chemotherapy or radiotherapy. A compound of a general formula (I): wherein A means an aryl group or a heteroaryl group, or a group of a formula (a):; R1 means a -(C=O)aOb(C1-C6)alkyl group, a -(C=O)aOb(C2-C6)alkenyl group, a -(C=O)aOb(C3-C6)cycloalkyl group, an aryl group or a heteroaryl group; R2 and R3 each mean a hydrogen atom, a halogen atom, a hydroxyl group, a carboxyl group, a -(C=O)aOb(C1-C6)alkyl group or a group of -(C=O)aN(R1e)R2e; R4 means a hydrogen atom or a (C1-C6)alkyl group, and the like have an excellent Wee1-kinase-inhibitory effect, and are therefore useful in the field of medicine, especially in the field of various cancer treatments.</p> |
申请公布号 |
WO2010098367(A1) |
申请公布日期 |
2010.09.02 |
申请号 |
WO2010JP52910 |
申请日期 |
2010.02.18 |
申请人 |
BANYU PHARMACEUTICAL CO.,LTD.;GOTO, YASUHIRO;NIIYAMA, KENJI;SUNAMI, SATOSHI;TAKAHASHI, KEIJI |
发明人 |
GOTO, YASUHIRO;NIIYAMA, KENJI;SUNAMI, SATOSHI;TAKAHASHI, KEIJI |
分类号 |
A61P43/00;C07D519/00;C07D487/14;A61K31/519;A61K31/5377;A61K31/538;A61K31/551;A61P35/00 |
主分类号 |
A61P43/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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