发明名称 |
REGULATORY B CELLS AND THEIR USES |
摘要 |
The present invention relates to a phenotypically distinct CD1dhighCD5+ B cell subset that regulates T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-IO). The invention also relates to the use of these IL-IO producing regulatory B cells in the manipulation of immune and inflammatory responses, and in the treatment of disease. Therapeutic approaches involving adoptive transfer of these regulatory B cells, or expansion of their endogenous levels for controlling autoimmune or inflammatory diseases and conditions are described. Ablation of this subset of regulatory B cells, or inhibition of their IL-IO production can be used to upregulate immunodeficient conditions, and/or to treat tumors/cancer. Diagnostic applications also are encompassed. |
申请公布号 |
WO2009131712(A3) |
申请公布日期 |
2010.09.02 |
申请号 |
WO2009US02560 |
申请日期 |
2009.04.27 |
申请人 |
DUKE UNIVERSITY;TEDDER, THOMAS, F.;YANABA, KOICHI;BOUAZIZ, JEAN-DAVID |
发明人 |
TEDDER, THOMAS, F.;YANABA, KOICHI;BOUAZIZ, JEAN-DAVID |
分类号 |
A61K35/14;A61P35/00;A61P37/04 |
主分类号 |
A61K35/14 |
代理机构 |
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