DRUG DISCOVERY METHOD

摘要

The application discloses a method for selecting Hepatitis C (HCV) inhibitors that form long-lived, tight complexes (EI complex) with their targets (eg NS3/4a protease). It also discloses the compound VX-950 which has such properties and its medical use for treating HCV infection and eliminating HCV contamination. The use of cellular viral replication assays for selecting viral inhibitors are equally claimed.