ENGINEERED MICROORGANISMS FOR THE PRODUCTION OF ONE OR MORE TARGET COMPOUNDS

摘要

Recombinant microorganisms comprising an isobutanol producing metabolic pathway with one or more isobutanol pathway enzymes localized in the mitochondria and methods of using said recombinant microorganisms to produce isobutanol are provided. The recombinant microorganisms may be Crabtree-negative yeast microorganisms, microorganisms of the Saccharomyces clade, Crabtree- positive yeast microorganisms, postwaD (whole genome duplication) yeast microorganisms, prß-WaD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.