摘要 |
Methods of treating fluid retention disorders with the B isomers of guanylin family peptides are described herein. UgnB, when compared to the A isomer (UgnA), exhibits a conventional sigmoidal dose-response relationship in its natriuetic activity. Further, unlike UgnA, UgnB only weakly activates the GC-C receptor. Compositions comprising purified, or mixtures containing B isomers of guanylin family peptides are described herein are therefore useful for the treatment of fluid retention disorders. |
申请人 |
IRONWOOD PHARMACEUTICALS, INC.;THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;CURRIE, MARK, G.;GOY, MICHAEL, F.;KESSLER, MARCO, M.;MOSS, NICHOLAS, G.;SOLINGA, ROBERT, MARCEL;ZIMMER, DANIEL, P. |
发明人 |
CURRIE, MARK, G.;GOY, MICHAEL, F.;KESSLER, MARCO, M.;MOSS, NICHOLAS, G.;SOLINGA, ROBERT, MARCEL;ZIMMER, DANIEL, P. |