发明名称 |
ANTIGEN-BINDING CONSTRUCTS |
摘要 |
The invention relates to a combination of RANKL antagonists with OSM antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof. |
申请公布号 |
WO2010097386(A1) |
申请公布日期 |
2010.09.02 |
申请号 |
WO2010EP52284 |
申请日期 |
2010.02.23 |
申请人 |
GLAXO GROUP LIMITED;HAMBLIN, PAUL ANDREW;PARMAR, RADHA SHAH;WHITE, JOHN |
发明人 |
HAMBLIN, PAUL ANDREW;PARMAR, RADHA SHAH;WHITE, JOHN |
分类号 |
C07K16/24;C07K16/28;C07K16/46 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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