发明名称 |
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
摘要 |
This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation. |
申请公布号 |
AU2010212273(A1) |
申请公布日期 |
2010.09.02 |
申请号 |
AU20100212273 |
申请日期 |
2010.08.11 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
ZHIWEN ZHANG;LITAL ALFONTA;PETER SCHULTZ |
分类号 |
C07K1/00;A61K38/43;C07H21/02;C07K14/47;C12N9/00;C12P21/06 |
主分类号 |
C07K1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|