| 摘要 |
<p>The invention concerns a device for measuring the bioadhesiveness of a mucoadhesive preparation which comprises: (i) an environmental chamber, (ii) a plane 1 that can be inclined by 45° and more, (iii) a graduated metal or plastic support 2, (iv) two biological membranes M, one being a reference membrane impregnated with water or with a buffer solution and one being a measuring membrane impregnated with a solution comprising a biological component, (v) a system for impregnating the biological membranes, (vi) a system 5 for injecting the test preparation, (vii) a system for timing the flow time of each sample injected, (viii) and a system for calculating the bioadhesiveness factor represented by a difference in flow time between the membrane impregnated with the biological component and the reference membrane. Uses: devices for determining the bioadhesiveness of preparations intended to be applied to the mucous membranes or the skin.</p> |
