发明名称 |
2-Thiophen-2-yl-oxazole, 2-Thiophen-2-yl-thiazole and 2-Thiophen-2-yl-1H-imidazole derivatives as antiviral agents |
摘要 |
The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
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申请公布号 |
EP2223921(A1) |
申请公布日期 |
2010.09.01 |
申请号 |
EP20100003376 |
申请日期 |
2006.01.24 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
NAN, FAJUN;ZUO, JIANPING;WANG, WENLONG;WANG, GUIFENG;CHEN, HAIJUN;HE, PEILAN |
分类号 |
C07D417/04;A61K31/41;A61K31/42;A61K31/425;C07D403/04;C07D405/04;C07D407/04;C07D409/04;C07D413/04;C07D413/14;C07D417/14 |
主分类号 |
C07D417/04 |
代理机构 |
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地址 |
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