| 发明名称 |
Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
| 摘要 |
<p>The present invention concerns a nucleic acid construct comprising:
(a) a first polynucleotide region encoding a chimeric polypeptide which comprises an extracellular region of TNFR1 fused to the transmembrane and intracellular regions of Fas; and
(b) a second polynucleotide region comprising an endothelial specific promoter operably linked to said first polynucleotide region.</p> |
| 申请公布号 |
EP2223932(A1) |
申请公布日期 |
2010.09.01 |
| 申请号 |
EP20090176343 |
申请日期 |
2002.05.01 |
| 申请人 |
VASCULAR BIOGENICS LTD. |
发明人 |
GREENBERGER, SHOSHANA;HARATS, DROR;BREITBART, EYAL |
| 分类号 |
C07H21/04;C12N15/09;A61K38/00;A61K38/17;A61K48/00;A61P9/00;A61P35/00;A61P43/00;C12N5/10;C12N15/861 |
主分类号 |
C07H21/04 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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