发明名称 |
Metalloprotein inhibitors |
摘要 |
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
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申请公布号 |
US7786316(B2) |
申请公布日期 |
2010.08.31 |
申请号 |
US20090503190 |
申请日期 |
2009.07.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PUERTA DAVID T.;COHEN SETH M.;LEWIS JANA A. |
分类号 |
C07D315/00;A61K31/167;A61K31/35;A61K31/435;C07D211/72;C07D213/69;C07D309/36;C07D309/38;C07D309/40 |
主分类号 |
C07D315/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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