IMPROVEMENT OF HOMOGENEITY AND SECRETION OF RECOMBINANT PROTEINS IN MAMMALIAN SYSTEMS

摘要

The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH. The invention also relates to DNA expression vectors containing the sequence encoding such proteins fused to the signal peptide sequence of the hGH and to cells harboring such vectors.