发明名称 |
Adenovirus E1B-55K single amino acid mutants and methods of use |
摘要 |
Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.
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申请公布号 |
US7785887(B2) |
申请公布日期 |
2010.08.31 |
申请号 |
US20030669768 |
申请日期 |
2003.09.24 |
申请人 |
ONYX PHARMACEUTICALS, INC. |
发明人 |
SHEN YUQIAO;NYE JULIE;HERMISTON TERRY |
分类号 |
C12N15/09;C12N15/861;A01N63/00;A61K9/127;A61K31/7105;A61K31/711;A61K35/02;A61K35/76;A61K38/00;A61K38/16;A61K48/00;A61P35/00;C07K14/075;C12N7/00;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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