PYRIDO- AND PYRIMIDOPYRIMIDINE DERIVATIVES AS ANTI- PROLIFERATIVE AGENTS

摘要

The present invention concerns the compounds of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A-a=a-arepresents a divalent radical selected from N-CH=CH-CH, N-CH=N-CH or CH-CH=N-CH; Z represents NH; Y represents -Calkyl-, -Calkyl-NR-Calkyl-,-Calkyl-NH-CO- or -CO-NH-Calkyl-; Xrepresents -O- or -NR; Xrepresents a direct bond, -O-, -N (R)-Calkyl-, -N (R)-C(O)-Calkyl-, Het-Calkyl; Rrepresents hydrogen or halo; Rrepresents hydrogen or halo; Ris hydrogen; Ris hydrogen; Ris hydrogen; Ris hydrogen or Calkyl; Ris hydrogen; Ris hydrogen; Ris hydrogen; Hetis heterocycle selected from pyrrolidinyl, 2-pyrrolidinyl.