发明名称 SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS
摘要 Disclosed are spirocyclic compounds of the general formula la, where the sub-rings A and B are in each case the same or different and are each independently a) a saturated or partly saturated cycloalkyl, in which cycloalkyl is unbridged, bridged or fused and is unsubstituted or independently, according to the ring size, mono-, di-, tri, tetra- or pentasubstituted by R4, or b) a saturated or partly saturated, heterocycle which, according to the ring size, may contain one, two, three or four identical or different heteroatoms from the group of oxygen, nitrogen or sulphur, and in which the heterocycle is unbridged, bridged or fused and is unsubstituted or independently, according to the ring size, mono-, di-, tri-, tetra- or pentasubstituted by R4; and wherein the remaining substituents are as defined herein. Also disclosed is a medicament which comprises a compound of the formula la as defined above together with a pharmaceutically suitable and physiologically compatible carrier, additive and/or other active ingredients and/or excipients.
申请公布号 NZ573049(A) 申请公布日期 2010.08.27
申请号 NZ20070573049 申请日期 2007.05.23
申请人 SANOFI-AVENTIS 发明人 SCHUDOK, MANFRED;WAGNER, MICHAEL;BAUER, ARMIN;KOHLMANN, ANNA
分类号 C07D211/66;A61K31/438;A61P19/00;A61P35/00;C07C237/24;C07D213/26;C07D231/54;C07D263/52;C07D295/215;C07D295/26;C07D317/72;C07D471/10;C07D491/10;C07D498/10 主分类号 C07D211/66
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