Crystalline forms of duloxetine free base

摘要

Disclosed is a duloxetine free base in crystalline form as well as specific forms A, B and C. Also disclosed is the process of preparing crystalline duloxetine free base comprising dissolving or suspending a salt of duloxetine in a suitable medium, neutralzing with a suitable base, extracting the thus formed duloxetine free base into a suitable solvent, replacing the solvent with a non-solvent, and thus isolating duloxetine free base in crystalline form. Also disclosed is the use of crystalline duloxetine free base in the manufacture of a medicament for treating depression.