INHIBITOR OF ASPARTYL PROTEASE

摘要

<P>PROBLEM TO BE SOLVED: To provide a new class of sulfonamides which are aspartyl protease inhibitors. Ž<P>SOLUTION: In one embodiment, this invention relates to a new class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl proteases using the compounds and methods for screening compounds for anti-HIV activity. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž