SOLID FORMS OF ( 2R) -2- { ( IS ) -6, 7 -DIMETHOXY- 1- [2- (4-TRIFLU0R0METHYL-PHENYL) -ETHYL] -3, 4-DIHYDR0-1H -ISOQUINOLIN-2-YL} -N-METHYL-2-PHENYL-ACETAMIDE HYDROCHLORIDE

摘要

The invention relates to hydrated crystalline forms of (2R)-2-{(1 S)-6,7-dimethoxy-1 - [2-(4-thfluoromethyl-phenyl)-ethyl]-3,4-dihydro-1 H-isoquinolin-2-yl}-?/-methyl-2- phenyl-acetamide hydrochloride, to the amorphous form of this compound, and to further crystalline forms of this compound, to processes for the preparation thereof, pharmaceutical compositions containing said crystalline forms or said amorphous form, and their use as orexin receptor antagonists.