发明名称 |
Hydroxypropyl Substitution Used to Regulate Dissolution of a Chemical |
摘要 |
A method of producing a batch of a tetracycline-class component HPMC extended release pharmaceutical product having a desired dissolution profile, comprising: selecting a dissolution rate-controlling polymer comprising an HPMC component, the HPMC component having a selected % HP value; validating that the % HP in the selected HPMC component is such that a mean sample of the product complies with the desired dissolution profile over each time point in the dissolution profile, and preparing the product by preparing a formulation comprising a pharmaceutically effective amount of the tetracycline-class chemical and the selected HPMC component with the % HP value. There is also provided a method of predicting the dissolution rate profile over a number of dosage forms.
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申请公布号 |
US2010215744(A1) |
申请公布日期 |
2010.08.26 |
申请号 |
US20100756962 |
申请日期 |
2010.04.08 |
申请人 |
MEDICIS PHARMACEUTICAL CORPORATION |
发明人 |
WATT DAVID;NEWHARD STEVEN B. |
分类号 |
A61K9/22;A61K31/65;A61P43/00 |
主分类号 |
A61K9/22 |
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