| 摘要 |
The present invention relates to an improved process for the preparation of 4-[5-(4- methy lphenyl)-3-(trifluoromethyl)-1H-pyrazol- 1-yl]benzenesulfonamide of Formula (I), by condensing 1-(4-methylphenyl)-4,4,4-trifluorobutane-1,3-dione (IV), Formula (IV) with 4-hydrazinophenylsulfonamide (V) or its acid addition salt Formula (V) in a solvent selected from water and in presence of acid. The present invention also relates to the process for the purification of Celecoxib in a solvent mixture. |
| 申请人 |
AUROBINDO PHARMA LIMITED;AMBATI, V RAGHAVA REDDY;GARAGA, SRINIVAS;MALLELA, SAMBHU PRASAD SARMA;MEENAKSHISUNDERAM, SIVAKUMARAN |
发明人 |
AMBATI, V RAGHAVA REDDY;GARAGA, SRINIVAS;MALLELA, SAMBHU PRASAD SARMA;MEENAKSHISUNDERAM, SIVAKUMARAN |
