| 摘要 |
Condensed tricyclic pyrazole compounds having affinity for the CB1 and/or CB2 cannabinoidergic receptors, with activity both on the peripheral and central nervous system, of formula (I): wherein: A represents a group selected from—(CH2)t—,—(CH2)r—O—(CH2)s—and—(CH2)r—S(O)p—(CH2)s—B is an heteroaryl, R is a group selected from heteroaryl, heteroarylalkyl, aryl, arylalkyl, arylalkenyl or bivalent aliphatic chain, R′is a group selected from the following: R′1: a substituent bearing a keto group of formula—C(O)—(Z′)v—Z″R′2: a substituent having an hydroxylic function of formula—CH(OH)—(Z′)v-Z″, R′3: an amide substituent of formula—C(O)—NH—(Z′)v-T′. |
