发明名称 |
MONOCLONAL ANTIBODY PRODUCTION IN B CELLS AND USES THEROF |
摘要 |
The presently disclosed subject matter provides methods of inhibiting a host innate response to activator-mediated proliferative signals in a primary B cell. In some embodiments a method is provided for immortalized primary B cells. In some embodiments a method is provided for increasing efficiency of EBV transformation of primary B cells. In some embodiments a method is provided for increasing proliferation of primary B cells in culture. In some embodiments a method is provided for producing a monoclonal antibody. In some embodiments a method is provided for identifying a novel broadly neutralizing antibody having a desired antigen specificity. Also provided are antibodies produced according the methods of the presently disclosed subject matter. |
申请公布号 |
WO2010053987(A3) |
申请公布日期 |
2010.08.26 |
申请号 |
WO2009US63271 |
申请日期 |
2009.11.04 |
申请人 |
DUKE UNIVERSITY;HWANG, KWAN-KI;LUFTIG, MICAH |
发明人 |
HWANG, KWAN-KI;LUFTIG, MICAH |
分类号 |
C12N5/0781;C07K16/08;C07K16/18;C12N5/10 |
主分类号 |
C12N5/0781 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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