| 摘要 |
<P>PROBLEM TO BE SOLVED: To identify a modified form of neublastin exhibiting prolonged bioavailability. Ž<P>SOLUTION: A dimer comprising a mutated neublastin polypeptide coupled to a polymer is provided. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin. A pharmacological composition containing the dimer, a vector expressing a DNA encoding a nucleic acid (e.g. a polypeptide to be incorporated into the dimer), a host cell transformed with the nucleic acid, and a method for treating neuropathic pain in a mammal are provided. Ž<P>COPYRIGHT: (C)2010,JPO&INPIT Ž
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