FLUOROPHENYL OXAZOLE DERIVATIVES INHIBITING PEPTIDE SYNTHESIS WITH ANTI-FUNGAL ACTIVITY, A PREPARATION METHOD THEREOF, AND A USE COMPRISING THE SAME

摘要

PURPOSE: A fluorophenyl oxazole derivative with antifungal activity is provided to selectively suppress protein synthesis of pathogenic fungus and to use as various antifungal agents. CONSTITUTION: A fluorophenyl oxazole derivative is denoted by chemical formula 1. A method for preparing fluorophenyl oxazole derivative or pharmaceutically acceptable salt thereof comprises: a step of performing nitration of a compound of chemical formula 6 to obtain a compound of chemical formula 7; a step of reducing the nitro compound of chemical formula 7 to obtain hydroxyl amine compound of chemical formula 8; a step of performing acylation of the hydroxy amine compound of chemical formula 8 with a compound of chemical formula 9 to obtain an amide compound of chemical formula 10; and a step of cyclizing the amide compound of chemical formula 10 to obtain the compound of chemical formula 1.